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    • Ghana, Kenya, South Africa, Tanzania, Uganda - Epidemiology and Treatment of Epilepsy in sub-Saharan Africa

    Epidemiology
    Reference ID INDEPTH.GH002.SEEDS.v1
    Year 2007 - 2008
    Country Ghana, Kenya, South Africa, Tanzania, Uganda
    Producer(s) Prof C R Newton - Dept of Psychiatry, University of Oxford, UK and KEMRI/Wellcome Trust Research Programme, Centre for Geographic Medicine Research–Coast, Kilifi , Kenya.
    Anthony K Ngugi - Dept
    Sponsor(s) Wellcome Trust Senior Fellowship in Clinical Tropical Medicine - WT - Funder
    Wellcome Trust Research Programme - WT - Funder
    University of the Witwatersrand - Wits - Partial support at Agincourt
    South African Medical Research Council - MRC
    Collection(s)
    Epidemiology and Treatment of Epilepsy in sub-Saharan Africa
    Created on
    Aug 29, 2013
    Last modified
    Dec 29, 2013
    Page views
    200052
    Sampling
    Sampling Procedure

    Sample size calculations. With an anticipated prevalence of at least 4/1,00016,20,159,160, in a DSS of at least 60,000 subjects, the 95% limits will be 3.5-4.5/1,000 at each site, or 3.8-4.2/1000 for the sites combined. For age-specific prevalences, confidence limits will be 2.3-5.7/1,000 in the smallest age stratum (>50 years) in the smallest site.

    A random population sample from each centre's census database with the RAND() command in MySQL (Oracle, Redwood Shores, CA, USA).

    For each case, an age-matched control individual was randomly selected from the relevant centre's census database with the RAND() command. The control individuals were frequency matched by age groups: 0-5 years, 6-12 years, 13-18 years, 19-28 years, 29-49 years, and 50 years or older. In the case-control study, two or three control individuals were selected to compensate for non-response and ensure balance in the number of cases and control individuals at each centre. All control individuals were assessed by a clinician to confirm that they did not have epilepsy.

    Deviations from Sample Design

    None reported

    Response Rate

    Stage One:
    Kilifi , Kenya 99.3%
    Agincourt, South Africa 99.6%
    Iganga-Mayuge, Uganda 92.8%
    Ifakara, Tazania 89.3%
    Kintampo, Ghana 87.7%
    Overall 94.5%

    Stage Two
    Kilifi , Kenya 94.8%
    Agincourt, South Africa 94.3%
    Iganga-Mayuge, Uganda 64.0%
    Ifakara, Tazania 95.1%
    Kintampo, Ghana 91.1%
    Overall 84.1%

    Stage Three
    Kilifi , Kenya 84.4%
    Agincourt, South Africa 92.7%
    Iganga-Mayuge, Uganda 64.2%
    Ifakara, Tazania 91.1%
    Kintampo, Ghana 77.7%
    Overall 82.0%